By now, everyone knows that medication development for mental disorders has hit a wall, pharmaceutical companies have abandoned the search for new medications, and there are no promising new medications on the horizon.1 So it is important to take a moment to consider ketamine, an anesthetic that has been around for decades. Intravenous ketamine was the anesthetic of choice for outpatient procedures in children when I was in medical training nearly 40 years ago. Twenty years ago ketamine achieved notoriety as a recreational drug under the moniker “Special K.” But in the past decade, ketamine has emerged as a potential antidepressant.