{"id":32,"date":"2023-11-05T04:57:29","date_gmt":"2023-11-05T04:57:29","guid":{"rendered":"http:\/\/fieldtriphealth.ca\/?page_id=32"},"modified":"2026-07-15T15:51:52","modified_gmt":"2026-07-15T19:51:52","slug":"science","status":"publish","type":"page","link":"https:\/\/fieldtriphealth.ca\/fr\/science\/","title":{"rendered":"La science"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"32\" class=\"elementor elementor-32\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-65470bc e-flex e-con-boxed e-con e-parent\" data-id=\"65470bc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a472358 elementor-widget-mobile__width-initial elementor-widget elementor-widget-heading\" data-id=\"a472358\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Independent Research &amp; Publications<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f79cf5 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"6f79cf5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Below is a collection of peer-reviewed studies exploring psychedelic science, neuroscience, and mental-health research.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-365c14a elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"365c14a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The following articles are independent scientific studies published in peer-reviewed journals.\nThey are provided for educational purposes only and do not represent treatment advice, clinical guidance, or outcomes associated with Field Trip Health.\nSome substances discussed in these studies\u2014such as psilocybin or MDMA\u2014are not approved for therapeutic use in Canada outside of authorized clinical research.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae73e67 e-flex e-con-boxed e-con e-parent\" data-id=\"ae73e67\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e392b3e e-con-full e-flex e-con e-child\" data-id=\"e392b3e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-48ec54c elementor-grid-2 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"48ec54c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;template_id&quot;:&quot;3712&quot;,&quot;columns&quot;:2,&quot;columns_tablet&quot;:1,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:80,&quot;sizes&quot;:[]},&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:60,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t<style id=\"loop-3712\">.elementor-3712 .elementor-element.elementor-element-7296b92{--display:flex;--flex-direction:column;--container-widget-width:100%;--container-widget-height:initial;--container-widget-flex-grow:0;--container-widget-align-self:initial;--flex-wrap-mobile:wrap;--gap:22px 22px;--row-gap:22px;--column-gap:22px;}.elementor-3712 .elementor-element.elementor-element-f35f180{--display:flex;--flex-direction:row;--container-widget-width:initial;--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--gap:30px 30px;--row-gap:30px;--column-gap:30px;}.elementor-widget-heading .elementor-heading-title{font-family:var( --e-global-typography-primary-font-family ), Sans-serif;font-weight:var( --e-global-typography-primary-font-weight );color:var( --e-global-color-primary );}.elementor-3712 .elementor-element.elementor-element-b01f686 .elementor-heading-title{font-family:\"Sofia Pro\", Sans-serif;font-size:13px;font-weight:600;text-transform:uppercase;line-height:18px;letter-spacing:1px;color:#EBE79D;}.elementor-3712 .elementor-element.elementor-element-7ecad07 .elementor-heading-title{font-family:\"Sofia Pro\", Sans-serif;font-size:13px;font-weight:600;text-transform:uppercase;line-height:18px;letter-spacing:1px;color:#FFFFFF;}.elementor-3712 .elementor-element.elementor-element-14296e0{--display:flex;}.elementor-3712 .elementor-element.elementor-element-b1c2aad .elementor-heading-title{font-family:\"Cooper BT\", Sans-serif;font-size:30px;font-weight:500;line-height:40px;color:#28223D;}.elementor-widget-theme-post-content{color:var( --e-global-color-text );font-family:var( --e-global-typography-text-font-family ), Sans-serif;font-weight:var( --e-global-typography-text-font-weight );}.elementor-3712 .elementor-element.elementor-element-8545467{color:#1F1B24;font-family:\"Sofia Pro\", Sans-serif;font-size:18px;font-weight:400;line-height:27px;}@media(min-width:768px){.elementor-3712 .elementor-element.elementor-element-7296b92{--content-width:500px;}}@media(max-width:1024px) and (min-width:768px){.elementor-3712 .elementor-element.elementor-element-7296b92{--content-width:100%;}}@media(max-width:1024px){.elementor-3712 .elementor-element.elementor-element-14296e0{--padding-top:0px;--padding-bottom:0px;--padding-left:0px;--padding-right:0px;}}@media(max-width:767px){.elementor-3712 .elementor-element.elementor-element-14296e0{--padding-top:0px;--padding-bottom:0px;--padding-left:0px;--padding-right:0px;}.elementor-3712 .elementor-element.elementor-element-b1c2aad .elementor-heading-title{font-size:24px;line-height:32px;}.elementor-3712 .elementor-element.elementor-element-8545467{font-size:16px;line-height:24px;}}<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"3712\" class=\"elementor elementor-3712 e-loop-item e-loop-item-3698 post-3698 science type-science status-publish hentry\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<a class=\"elementor-element elementor-element-7296b92 e-flex e-con-boxed e-con e-parent\" data-id=\"7296b92\" data-element_type=\"container\" data-e-type=\"container\" href=\"https:\/\/www.nature.com\/articles\/s41386-022-01266-9\" target=\"_blank\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f35f180 e-con-full e-flex e-con e-child\" data-id=\"f35f180\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ecad07 elementor-widget elementor-widget-heading\" data-id=\"7ecad07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">janvier 2022<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14296e0 e-con-full e-flex e-con e-child\" data-id=\"14296e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1c2aad elementor-widget elementor-widget-heading\" data-id=\"b1c2aad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Dose-related effects of psychedelic or antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8545467 elementor-widget elementor-widget-theme-post-content\" data-id=\"8545467\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">This study tested the efficacy of repeated intravenous psychedelic doses to reduce symptoms of posttraumatic stress disorder (PTSD). Veterans and service members with PTSD (n\u2009=\u2009158) who failed previous antidepressant treatment were randomized to 8 infusions administered twice weekly of intravenous placebo (n\u2009=\u200954), low dose (0.2\u2009mg\/kg; n\u2009=\u200953) or standard dose (0.5\u2009mg\/kg; n\u2009=\u200951) psychedelic. Participants were assessed at baseline, during treatment, and for 4 weeks after their last infusion. Primary analyses used mixed effects models. The primary outcome measure was the self-report PTSD Checklist for DSM-5 (PCL-5), and secondary outcome measures were the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) and the Montgomery \u00c5sberg Depression Rating Scale (MADRS). There were no significant group-by-time interactions for PTSD symptoms measured by the PCL-5 or CAPS-5. The standard psychedelic dose ameliorated depression measured by the MADRS significantly more than placebo. Psychedelics produced dose-related dissociative and psychotomimetic effects, which returned to baseline within 2\u2009h and were less pronounced with repeated administration. There was no evidence of differential treatment discontinuation by psychedelic dose, consistent with good tolerability. This clinical trial failed to find a significant dose-related effect of psychedelics on PTSD symptoms. Secondary analyses suggested that the standard dose exerted rapid antidepressant effects. Further studies are needed to determine the role of psychedelic in PTSD treatment.<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"3712\" class=\"elementor elementor-3712 e-loop-item e-loop-item-3703 post-3703 science type-science status-publish hentry\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<a class=\"elementor-element elementor-element-7296b92 e-flex e-con-boxed e-con e-parent\" data-id=\"7296b92\" data-element_type=\"container\" data-e-type=\"container\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2021.797577\/full\" target=\"_blank\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f35f180 e-con-full e-flex e-con e-child\" data-id=\"f35f180\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ecad07 elementor-widget elementor-widget-heading\" data-id=\"7ecad07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">janvier 2022<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14296e0 e-con-full e-flex e-con e-child\" data-id=\"14296e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1c2aad elementor-widget elementor-widget-heading\" data-id=\"b1c2aad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Psychedelic Treatment for Mood Disorders in Women<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8545467 elementor-widget elementor-widget-theme-post-content\" data-id=\"8545467\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">Psychedelics have been shown to acutely and rapidly ameliorate depression symptoms and suicidality. Given that women suffer from major depression at twice the rate of men, it is important to understand how psychedelics work in the female brain. This review explores three themes. First, it examines our current understanding of the etiology of depression in women. Second, it examines preclinical research on the psychedelic&#8217;s antidepressant effects at a neurobiological level, as well as how ovarian hormones present a unique challenge in interpreting these findings. Lastly, the neuroinflammatory hypothesis of depression is highlighted to help better understand how ovarian hormones might interact with psychedelics in the female brain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"3712\" class=\"elementor elementor-3712 e-loop-item e-loop-item-3790 post-3790 science type-science status-publish hentry\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<a class=\"elementor-element elementor-element-7296b92 e-flex e-con-boxed e-con e-parent\" data-id=\"7296b92\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f35f180 e-con-full e-flex e-con e-child\" data-id=\"f35f180\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ecad07 elementor-widget elementor-widget-heading\" data-id=\"7ecad07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">janvier 2022<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14296e0 e-con-full e-flex e-con e-child\" data-id=\"14296e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1c2aad elementor-widget elementor-widget-heading\" data-id=\"b1c2aad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Adjunctive Psychedelics With Relapse Prevention\u2013Based Psychological Therapy in the Treatment of Alcohol Use Disorder<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8545467 elementor-widget elementor-widget-theme-post-content\" data-id=\"8545467\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">Early evidence suggests that psychedelics may be an effective treatment to sustain abstinence from alcohol. The authors investigated the safety and efficacy of psychedelics compared with a placebo in increasing abstinence in patients with alcohol use disorder. An additional aim was to pilot psychedelics combined with mindfulness-based relapse prevention therapy compared with a psychedelic and alcohol education as a therapy control.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"3712\" class=\"elementor elementor-3712 e-loop-item e-loop-item-3700 post-3700 science type-science status-publish hentry\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<a class=\"elementor-element elementor-element-7296b92 e-flex e-con-boxed e-con e-parent\" data-id=\"7296b92\" data-element_type=\"container\" data-e-type=\"container\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34983255\/\" target=\"_blank\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f35f180 e-con-full e-flex e-con e-child\" data-id=\"f35f180\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ecad07 elementor-widget elementor-widget-heading\" data-id=\"7ecad07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">janvier 2022<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14296e0 e-con-full e-flex e-con e-child\" data-id=\"14296e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1c2aad elementor-widget elementor-widget-heading\" data-id=\"b1c2aad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8545467 elementor-widget elementor-widget-theme-post-content\" data-id=\"8545467\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">As their name suggests, &#8216;psychedelic&#8217; (mind-revealing) compounds are thought to catalyse processes of psychological insight; however, few satisfactory scales exist to sample this. This study sought to develop a new scale to measure psychological insight after a psychedelic experience: the Psychological Insight Scale (PIS).<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"3712\" class=\"elementor elementor-3712 e-loop-item e-loop-item-3706 post-3706 science type-science status-publish hentry\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<a class=\"elementor-element elementor-element-7296b92 e-flex e-con-boxed e-con e-parent\" data-id=\"7296b92\" data-element_type=\"container\" data-e-type=\"container\" href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt.2487\" target=\"_blank\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f35f180 e-con-full e-flex e-con e-child\" data-id=\"f35f180\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ecad07 elementor-widget elementor-widget-heading\" data-id=\"7ecad07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">novembre 2021<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14296e0 e-con-full e-flex e-con e-child\" data-id=\"14296e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1c2aad elementor-widget elementor-widget-heading\" data-id=\"b1c2aad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8545467 elementor-widget elementor-widget-theme-post-content\" data-id=\"8545467\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">The psychedelic psilocybin is being investigated for the treatment of depression and anxiety. Unclear is whether antidepressant treatments interact with psilocybin. The present study used a double-blind, placebo-controlled, crossover design with two experimental test sessions to investigate the response to psilocybin (25 mg) in healthy subjects after pretreatment with escitalopram or placebo. The treatment order was random and counterbalanced. Pretreatment consisted of 10 mg escitalopram daily for 7 days, followed by 20 mg daily for 7 days, including the day of psilocybin administration, or 14 days of placebo pretreatment before psilocybin administration. Psilocybin treatments were separated by at least 16 days. The outcome measures included self-rating scales that evaluated subjective effects, autonomic effects, adverse effects, plasma brain-derived neurotrophic factor (BDNF) levels, electrocardiogram QTc time, whole-blood HTR2A and SCL6A4 gene expression, and pharmacokinetics. Escitalopram pretreatment had no relevant effect on positive mood effects of psilocybin but significantly reduced bad drug effects, anxiety, adverse cardiovascular effects, and other adverse effects of psilocybin compared with placebo pretreatment. Escitalopram did not alter the pharmacokinetics of psilocin. The half-life of psychoactive free (unconjugated) psilocin was 1.8 hours (range 1.1-2.2 hours), consistent with the short duration of action of psilocybin. Escitalopram did not alter HTR2A or SCL6A4 gene expression before psilocybin administration, QTc intervals, or circulating BDNF levels before or after psilocybin administration. Further studies are needed with a longer antidepressant pretreatment time and patients with psychiatric disorders to further define interactions between antidepressants and psilocybin.<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"3712\" class=\"elementor elementor-3712 e-loop-item e-loop-item-3799 post-3799 science type-science status-publish hentry\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<a class=\"elementor-element elementor-element-7296b92 e-flex e-con-boxed e-con e-parent\" data-id=\"7296b92\" data-element_type=\"container\" data-e-type=\"container\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34734314\/\" target=\"_blank\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f35f180 e-con-full e-flex e-con e-child\" data-id=\"f35f180\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ecad07 elementor-widget elementor-widget-heading\" data-id=\"7ecad07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">novembre 2021<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14296e0 e-con-full e-flex e-con e-child\" data-id=\"14296e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1c2aad elementor-widget elementor-widget-heading\" data-id=\"b1c2aad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8545467 elementor-widget elementor-widget-theme-post-content\" data-id=\"8545467\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">The current study aimed to explore the subjective effects of psychedelics when used alongside cannabis.<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Independent Research &amp; Publications Below is a collection of peer-reviewed studies exploring psychedelic science, neuroscience, and mental-health research. The following articles are independent scientific studies published in peer-reviewed journals. They are provided for educational purposes only and do not represent treatment advice, clinical guidance, or outcomes associated with Field Trip Health. Some substances discussed in [&hellip;]<\/p>\n","protected":false},"author":26,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"class_list":["post-32","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.5 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Science - Field Trip Health<\/title>\n<meta name=\"description\" content=\"Explore the science behind psychedelic therapies at Field Trip Health, where cutting-edge research and clinical expertise drive advancements in mental health treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fieldtriphealth.ca\/fr\/science\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science\" \/>\n<meta property=\"og:description\" content=\"Explore the science behind psychedelic therapies at Field Trip Health, where cutting-edge research and clinical expertise drive advancements in mental health treatment.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fieldtriphealth.ca\/fr\/science\/\" \/>\n<meta property=\"og:site_name\" content=\"Field Trip Health\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/fieldtriphealthcanada\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-15T19:51:52+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@fieldtriphealth\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fieldtriphealth.ca\\\/science\\\/\",\"url\":\"https:\\\/\\\/fieldtriphealth.ca\\\/science\\\/\",\"name\":\"Science - 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